Electrochemical detection of cefiderocol for therapeutic drug monitoring

Cefiderocol is a novel siderophore-conjugated ?-lactam antibiotic which has been approved for clinical use. It demonstrated efficacy against infections caused by Gram-negative bacteria, including carbapenem-resistant strains. Novel antibiotics are rarely brought to market and, as such, ideal candidates therapeutic drug monitoring enables optimised dosing across range of scenarios whilst also reducing the chances antimicrobial resistance. Here we demonstrate direct electrochemical detection cefiderocol oxidation using untreated gold and glassy carbon electrodes well multi-walled nanotube (MWCNT)-coated foamed electrodes. Quantification in spiked whole human blood MWCNT-coated pyrolytic screen-printed